Hamzei E, Alavi A, Khorami Saber M, Azad M
Clinical Research Development Center of Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
Clinical Research Development Center of Shahid Mohammadi Hospital, Hormozgan University of Medical Sciences, Bandar Abbas, Iran; Student Research Committee, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
J Med Life. 2015;8(Spec Iss 4):52-55.
Stroke is a type of nervous focal disorder that occurs suddenly because of acute vascular events. 113-149 out of 100000 persons (0.113-0.149%) face with stroke in Iran annually. This causes treatment costs and many disabilities. Recently, studies indicated that statins, as a class of drugs, could decrease the chance of stroke recurrence and probably disabilities after stroke onset. This paper presents the effects of previous statins consumption on NIHSS in patients hospitalized in Shahid Mohammadi Hospital of Bandar Abbas in 2014-5. Based on the World Health Organization categorization, 140 patients suffered from stroke, experienced stroke once or more, and were older than 20 years old. They were studied with a simple convenience sampling in this descriptive study during 2014-5. The exclusion criteria were non-neurological vision disorders, ICH, and unwillingness of the patients to participate in the research. The patients were classified into two teams, one taking statin before the stroke onset (group A) and other taking no statins before stroke onset (group B). Patients were initially examined with the help of NIHSS rate measurement (using NIHSS rating standard questionnaire), type of stroke (ischemic or hemorrhagic), and other demographic data. Then the data were inserted into SPSS 22 and descriptive statistical tests (median, mean and standard deviation), Spearman and Mann-Whitney tests, were used due to the abnormal distribution of the data. 140 patients suffered from stroke (95 men (67.85%) and 45 women (32.14%)) with an average age of 67.9 years old, being studied in two groups (A and B). A direct correlation was seen between age and NIHSS (sig = 0.057) but it was not notable (P > 0.05). There was no clear relationship among sex, number of prior stroke onsets, type of stroke, lipid profile (TG, Total Cholesterol, LDL, HDL), blood sugar, underlying disease (diabetes, hypertension and ischemic heart diseases), drug abuse and history of hospitalization in ICI with NIHSS rate (P > 0.05). 106 patients (75.71%) have never taken any type of statin class of drugs and only 34 patients (24.28%) were taking these medications before the stroke. The difference between NIHSS rates of groups A and B was not clear and notable (P > 0.05). According to the findings of this research, taking statins before the onset of stroke and immediately after it showed no significant difference in the level of following dysfunction, measured with NIHSS, and further studies are necessary.
中风是一种由于急性血管事件而突然发生的神经局灶性疾病。伊朗每年每10万人中有113 - 149人（0.113 - 0.149%）患中风。这会导致治疗费用和许多残疾。最近，研究表明，他汀类药物作为一类药物，可以降低中风复发的几率，并可能减少中风发作后的残疾。本文介绍了2014 - 2015年在阿巴斯港沙希德·穆罕默迪医院住院的患者之前服用他汀类药物对美国国立卫生研究院卒中量表（NIHSS）评分的影响。根据世界卫生组织的分类，140名中风患者，经历过一次或多次中风，年龄超过20岁。在2014 - 2015年期间，本描述性研究采用简单便利抽样对他们进行了研究。排除标准为非神经性视力障碍、脑出血（ICH）以及患者不愿参与研究。患者被分为两组，一组在中风发作前服用他汀类药物（A组），另一组在中风发作前未服用他汀类药物（B组）。患者最初通过NIHSS评分测量（使用NIHSS评分标准问卷）、中风类型（缺血性或出血性）以及其他人口统计学数据进行检查。然后将数据录入SPSS 22，并由于数据分布异常而使用描述性统计测试（中位数、均值和标准差）、Spearman检验和Mann - Whitney检验。140名中风患者（95名男性（67.85%）和45名女性（32.14%）），平均年龄67.9岁，分为两组（A组和B组）进行研究。年龄与NIHSS评分之间存在直接相关性（sig = 0.057），但不显著（P > 0.05）。性别、既往中风发作次数、中风类型、血脂谱（甘油三酯、总胆固醇、低密度脂蛋白、高密度脂蛋白）、血糖、基础疾病（糖尿病、高血压和缺血性心脏病）、药物滥用以及在重症监护病房（ICU）的住院史与NIHSS评分之间均无明显关系（P > 0.05）。106名患者（75.71%）从未服用过任何类型的他汀类药物，只有34名患者（24.28%）在中风前服用过这些药物。A组和B组的NIHSS评分差异不明显且不显著（P > 0.05）。根据本研究结果，中风发作前及发作后立即服用他汀类药物，在用NIHSS测量的后续功能障碍水平上没有显著差异，需要进一步研究。
