Aulitzky W E, Hengster P, Tilg H, Schulz T, Dierich M, Huber C
Department for Internal Medicine, University Hospital, Innsbruck.
Wien Klin Wochenschr. 1988 Jan 22;100(2):33-43.
Interest has focused on cytomegalovirus (CMV) infections during recent years for two reasons: First, the number of immunocompromised patients with CMV infections has risen continuously and, secondly, recent advances in basic research have clarified some of the mechanisms of persistent and recurrent CMV infection. Three different clinical pictures can arise with CMV infection. In healthy individuals most of the CMV infections are not clinically apparent. In immunocompromised patients CMV causes a wide spectrum of diseases and is one of the predominant causes of death in AIDS patients and bone marrow transplant recipients. The most important problem for public health associated with CMV are connatal and perinatal CMV infections. Progress has been made with treatment of CMV infection in immunocompromised patients with inhibitors of viral replication.
近年来，人们对巨细胞病毒（CMV）感染的关注集中在两个原因上：第一，感染CMV的免疫功能低下患者数量持续上升；第二，基础研究的最新进展阐明了CMV持续感染和复发感染的一些机制。CMV感染可出现三种不同的临床症状。在健康个体中，大多数CMV感染没有临床症状。在免疫功能低下的患者中，CMV会引发多种疾病，是艾滋病患者和骨髓移植受者的主要死亡原因之一。与CMV相关的公共卫生最重要问题是先天性和围生期CMV感染。在使用病毒复制抑制剂治疗免疫功能低下患者的CMV感染方面已取得进展。
