Antigenotoxic Properties of against Hydrogen Peroxide in Human Peripheral Blood Cells.

The ability of mushroom in its dried and powdered mycelial form was evaluated for its antigenotoxic properties for the first time. Antigenotoxic effects in human peripheral blood cells against HO-induced DNA damage were examined in pretreatment and posttreatment protocol by comet assay. The results showed better antigenotoxic properties of on the interventional level, respectively, after treatment. in concentration of 250 g/mL after treatment was most efficient in regard to its action against DNA damage. The evaluation of repair kinetics showed decrease in HO induced DNA damage 15 min after the application of , reaching the maximum potency after 30 min. Analysis of antioxidant properties of revealed strong OH scavenging properties and moderate reducing power, while its DPPH scavenging ability was weak. In regard to our findings, we can conclude that our preliminary results demonstrated antigenotoxic properties of and its strong OH scavenging ability. Mechanisms underlying its properties should be further evaluated in in vivo studies.