Akhondi-Meybodi Mohsen, Ghane Marzieh, Akhondi-Meybodi Sara, Dashti Golnaz
Associate Professor, Department of Internal Medicine, Subspecialty in Gastroenterology and Hepatology, ShahidSadoughi University of Medical Sciences, Yazd, Iran.
Medical Student, Member of Student Research Committee, ShahidSadoughi University of Medical Sciences, Yazd, Iran.
Middle East J Dig Dis. 2017 Jan;9(1):39-48. doi: 10.15171/mejdd.2016.50.
BACKGROUND The number of patients with gastric cancer is growing worldwide. In Iran (in 2009) of 74067 new cases of cancer, 6886 were diagnosed as having gastric cancer. This study was conducted to investigate 5-year survival rate for gastric cancer in Yazd province, central Iran. METHODS In this descriptive study, the medical records of patients with gastric cancer were collected from the archives of Yazd hospitals from 2001 to 2008. The data gathered included age, sex, type of histopathology, site of involvement, cancer staging, and mode of treatment, which were analyzed using SPSS software version 11.5. To investigate the survival and the factors influencing the survival time of patients, which are the main objectives of this study, Kaplan-Meier method was used and Cox proportional hazards model was fitted to the data. To compare survival function in different subgroups, the log rank test or generalized Wilcoxon test was used. RESULTS 295 cases of gastric cancer were enrolled in the study. The mean age of the subjects was 59.3 ± 9 years. 5-year survival rate of the patients was calculated as 18% where the highest rate was 39% for the age group of 50-60 years and the lowest was 3% for the age group of above 80 years. 5-year survival rates in different groups were as follows: 32% in women, 13% in men; 16% in adenocarcinoma, 46% in other pathologies; 16% in gastric cardia involvement, 17% in antrum; 59% in stage 1, 31% in stage 2, 13% in stage 3, and 3% in stage 4. CONCLUSION The results of this study showed that age, stage of the cancer, mode of therapy, and type of histopathology affected the survival rate of gastric cancer. No significant association was found between the site of involvement and survival rate. In general, the survival rate for gastric cancer was low, which might be due to slow but steady progress of the disease and delayed referral of the patients.
背景 全球胃癌患者数量正在增加。在伊朗（2009年），74067例新发癌症病例中，有6886例被诊断为胃癌。本研究旨在调查伊朗中部亚兹德省胃癌患者的5年生存率。方法 在这项描述性研究中，收集了2001年至2008年亚兹德医院档案中胃癌患者的病历。收集的数据包括年龄、性别、组织病理学类型、受累部位、癌症分期和治疗方式，使用SPSS 11.5软件进行分析。为了调查患者的生存率以及影响生存时间的因素（这是本研究的主要目的），采用了Kaplan-Meier方法，并对数据拟合Cox比例风险模型。为了比较不同亚组的生存函数，使用了对数秩检验或广义Wilcoxon检验。结果 本研究纳入了295例胃癌患者。受试者的平均年龄为59.³±9岁。患者的5年生存率计算为18%，其中50 - 60岁年龄组的最高生存率为39%，80岁以上年龄组的最低生存率为3%。不同组的5年生存率如下：女性为32%，男性为13%；腺癌为16%，其他病理类型为46%；贲门受累为16%，胃窦为17%；1期为59%，2期为31%，3期为13%，4期为3%。结论 本研究结果表明，年龄、癌症分期、治疗方式和组织病理学类型影响胃癌的生存率。未发现受累部位与生存率之间存在显著关联。总体而言，胃癌的生存率较低，这可能是由于疾病进展缓慢但持续以及患者转诊延迟所致。
