Ryu Chang-Woo, Shin Hee Shup, Park Soonchan, Suh Sang Hyun, Koh Jun Seok, Choi Hye-Yeon
Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea.
Department of Neurosurgery, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University, Seoul, South Korea.
Neurointervention. 2017 Mar;12(1):20-30. doi: 10.5469/neuroint.2017.12.1.20. Epub 2017 Mar 6.
The Alberta Stroke Program Early CT Score (ASPECTS) was devised to quantify the extent of early ischemic changes in the middle cerebral artery territory on brain CT. We performed a systematic review and meta-analysis of studies that presented clinical outcomes and baseline ASPECTS in ischemic stroke patients managed with endovascular methods to validate the use of ASPECTS for risk prognostication.
We searched the MEDLINE, EMBASE, and Cochran databases for observational or interventional studies that reported clinical outcomes and baseline ASPECTS in ischemic stroke patients treated with endovascular methods. Data were pooled to perform a meta-analysis for comparisons of clinical outcomes between high and low ASPECTS patients.
A meta-analysis of 13 studies (six observational and seven interventional) revealed favorable outcomes (mRS sore 0-2 at 90 days) for high baseline ASPECTS (odds ratio=2.22; 95% CI: 1.74-2.86).
High ASPECTS is a predictor of favorable outcome after endovascular therapy for ischemic stroke.
阿尔伯塔卒中项目早期CT评分（ASPECTS）旨在量化脑CT上大脑中动脉区域早期缺血性改变的程度。我们对采用血管内治疗方法的缺血性卒中患者的临床结局和基线ASPECTS的研究进行了系统评价和荟萃分析，以验证ASPECTS用于风险预后评估的有效性。
我们检索了MEDLINE、EMBASE和Cochrane数据库，查找报告采用血管内治疗方法的缺血性卒中患者临床结局和基线ASPECTS的观察性或干预性研究。汇总数据以进行荟萃分析，比较高ASPECTS组和低ASPECTS组患者的临床结局。
对13项研究（6项观察性研究和7项干预性研究）进行的荟萃分析显示，高基线ASPECTS患者的预后良好（90天时改良Rankin量表评分0-2分）（比值比=2.22；95%置信区间：1.74-2.86）。
高ASPECTS是缺血性卒中血管内治疗后预后良好的预测指标。
