Somani Rani, Jaidka Shipra, Bajaj Neeti, Arora Sameksha
Professor and Head, Department of Paedodontics and Preventive Dentistry, D J College of Dental Sciences and Research, Modinagar 201204, Uttar Pradesh, India.
Professor, Department of Paedodontics and Preventive Dentistry, D J College of Dental Sciences and Research, Modinagar 201204, Uttar Pradesh, India.
J Oral Biol Craniofac Res. 2017 Jan-Apr;7(1):49-53. doi: 10.1016/j.jobcr.2015.11.007. Epub 2016 Feb 4.
Stem cells are undifferentiated cells that can differentiate into specialized cells. Recently, enormous growth has been seen in the recognition of stem cell-based therapies, which have the potential to ameliorate the life of patients with conditions that span from Parkinson's disease to cardiac ischemia to bone or tooth loss. This research has produced new but unexplored possibilities in the regeneration of different organs and tissues. Presently, research is focused on the proficiency of stem cells and their utilization in dentistry, which is gaining interest. The tooth is nature's "esteem" for these precious stem cells and there are a number of these cells in permanent and primary teeth, as well as in the wisdom teeth. Dental stem cells are easy, convenient, and affordable to collect. They hold promise for a range of very potential therapeutic applications, such as in the treatment of cancer, spinal cord injury, brain damage, myocardial infarction, hearing loss, diabetes, wound healing, baldness, etc. Since these cells were used to regenerate damaged tissue in medical therapy successfully, it is possible that the dentist in future might use stem cell to regenerate lost or damaged dental and periodontal structures. This paper reviews the current concepts, characteristics of stem cells in regeneration, and its subsequent uses in dentistry.
干细胞是未分化的细胞，能够分化为特化细胞。近年来，基于干细胞的疗法得到了广泛认可，这类疗法有潜力改善患有从帕金森病到心肌缺血再到骨质或牙齿缺失等各种病症患者的生活。这项研究在不同器官和组织的再生方面带来了新的但尚未探索的可能性。目前，研究聚焦于干细胞的效能及其在牙科领域的应用，这一领域正日益受到关注。牙齿是大自然对这些珍贵干细胞的“珍视”所在，恒牙、乳牙以及智齿中都存在大量此类细胞。牙科干细胞易于采集，方便且成本低廉。它们有望用于一系列极具潜力的治疗应用，比如治疗癌症、脊髓损伤、脑损伤、心肌梗死、听力丧失、糖尿病、伤口愈合、脱发等。由于这些细胞已成功用于医学治疗中受损组织的再生，未来牙医有可能利用干细胞来再生缺失或受损的牙齿及牙周结构。本文综述了干细胞在再生方面的当前概念、特性及其在牙科领域的后续应用。
