a Department of Cranio-Maxillofacial Surgery , Hospital of the University of Regensburg , Regensburg , Germany.
Expert Opin Biol Ther. 2018 Feb;18(2):187-196. doi: 10.1080/14712598.2018.1402004. Epub 2017 Nov 15.
Human dental stem cells can be obtained from postnatal teeth, extracted wisdom teeth or exfoliated deciduous teeth. Due to their differentiation potential, these mesenchymal stem cells are promising for tooth repair. Therefore, the development of dental tissue regeneration represents a suitable but challenging, target for dental stem cell therapies. Areas covered: Expert opinion:
In this review, the authors provide an overview of human dental stem cells and their properties for regeneration medicine. Numerous preclinical studies have shown that dental stem cells improve bone augmentation and healing of periodontal diseases. Clinical trials are ongoing to validate the clinical feasibility of these approaches. Dental stem cells are also important for basic research.
Dental stem cells offer numerous advantages for tooth repair and regeneration. Data obtained from different studies are encouraging. In the next few years, investigations on dental stem cells in basic research, pre-clinical research and clinical studies will pave the way to optimizing patient-tailored treatments for repair and regeneration of dental tissues.
人源性牙齿干细胞可从出生后的牙齿、拔出的智齿或自然脱落的乳牙中获得。由于其分化潜能，这些间充质干细胞在牙齿修复方面具有广阔的应用前景。因此，牙组织再生的发展代表了一种合适但具有挑战性的牙齿干细胞治疗目标。
专家意见：
在这篇综述中，作者概述了人源性牙齿干细胞及其在再生医学中的特性。大量的临床前研究表明，牙齿干细胞可促进骨增量和牙周病的愈合。目前正在进行临床试验以验证这些方法的临床可行性。牙齿干细胞对于基础研究也很重要。
牙齿干细胞为牙齿修复和再生提供了许多优势。不同研究获得的数据令人鼓舞。在未来几年，基础研究、临床前研究和临床研究中对牙齿干细胞的研究将为优化针对牙齿组织修复和再生的个体化治疗铺平道路。
