Gupta N D, Sharma Shweta, Sharma Vivek Kumar
Department of Periodontics & Community Dentistry, Dr Ziauddin Ahmad Dental College, Aligarh Muslim University, Aligarh, 202001, Uttar Pradesh, India.
J Oral Biol Craniofac Res. 2017 Jan-Apr;7(1):72-73. doi: 10.1016/j.jobcr.2016.09.002. Epub 2016 Sep 28.
One of the etiological factors in the pathogenesis of periodontitis is reduction or the absence of the so-called "beneficial bacteria". Most of the globally applied treatment approach is based on subgingival bacterial elimination but recolonization with less pathogenic bacteria is seen within weeks. Therefore, researchers have started focusing on shifting the current treatment approach from specific bacterial elimination to restoring periodontal pocket with beneficial bacteria. This alteration in the ecology of niches from the one with the pathological plaque to the one with the biofilm of commensals can be achieved via subgingival application of probiotics. This article suggests the important prospects of subgingival delivery of probiotics in guiding periodontal recolonization with beneficial bacteria and emphasizes research in this study field.
牙周炎发病机制中的病因之一是所谓“有益菌”数量减少或缺失。全球应用的大多数治疗方法都基于龈下细菌清除，但数周内会出现致病性较低的细菌重新定植。因此，研究人员已开始将当前的治疗方法从特定细菌清除转向用有益菌恢复牙周袋。通过龈下应用益生菌，可以实现从病理性菌斑生态位到共生生物膜生态位的这种生态改变。本文提出了龈下递送益生菌在引导有益菌进行牙周再定植方面的重要前景，并强调了该研究领域的研究。
