Nackaerts Olivia, Jacobs Reinhilde, Quirynen Marc, Rober Marleen, Sun Yi, Teughels Wim
Oral Imaging Center, School of Dentistry, Oral Pathology and Maxillo-Facial Surgery, Faculty of Medicine, K.U. Leuven, Belgium.
J Clin Periodontol. 2008 Dec;35(12):1048-52. doi: 10.1111/j.1600-051X.2008.01333.x.
The aim of this study was to radiologically evaluate the impact of replacement therapy by monitoring bone density changes and alveolar bone level in periodontal pockets in a dog model.
Eight male beagle dogs with moderate periodontitis were enrolled in this split-mouth, double-blind randomized trial with ethical approval. Periodontal defects were surgically created bilaterally in the lower jaw. Four months later, the defects were randomly assigned to initial therapy (scaling and root planing) alone (control sites), or combined with multiple subgingival application of beneficial species. Intra-oral follow-up radiography was performed at this stage and 3 months later to verify the treatment effect.
The bone density within periodontal pockets treated with beneficial bacteria improved significantly after 12 weeks, while this was non-significant for the control pockets, receiving a single root planing at baseline. There was a significant increase in the bone level at the end of the study for the pockets receiving beneficial bacteria. Again, no significance was noted for the control pockets.
This pilot study indicates the potential effect of a subgingival application of beneficial species in periodontal pockets, and illustrates the strength of standardized follow-up radiography to evaluate the effects of different treatment strategies on bone re-modelling.
本研究旨在通过监测犬模型中骨密度变化和牙周袋内牙槽骨水平，以放射学方式评估替代疗法的影响。
八只患有中度牙周炎的雄性比格犬纳入了这项经伦理批准的双盲随机对照分口试验。在下颌双侧手术制造牙周缺损。四个月后，将缺损随机分配至仅接受初始治疗（洁治和根面平整）（对照部位），或联合多次龈下应用有益菌种。在此阶段及3个月后进行口内随访放射照相，以验证治疗效果。
接受有益菌治疗的牙周袋内骨密度在12周后显著改善，而对照牙周袋在基线时仅接受一次根面平整，骨密度改善不显著。在研究结束时，接受有益菌治疗的牙周袋骨水平显著增加。对照牙周袋同样无显著变化。
这项初步研究表明了在牙周袋内龈下应用有益菌种的潜在效果，并说明了标准化随访放射照相在评估不同治疗策略对骨重塑影响方面的优势。
