Almeida Sintia, Sousa Cassiana, Abreu Vinícius, Diniz Carlos, Dorneles Elaine M S, Lage Andrey P, Barh Debmalya, Azevedo Vasco
Institute of Biologic Sciences, Federal University of Minas Gerais, 31270-901 Belo Horizonte, MG, Brazil.
Center for Nuclear Energy in Agriculture, University of Sao Paulo, 13400-970 Piracicaba, SP, Brazil.
Int J Genomics. 2017;2017:9481756. doi: 10.1155/2017/9481756. Epub 2017 Feb 20.
Based on the ability of nitrate reductase synthesis, is classified into two biovars: Ovis and Equi. Due to the presence of nitrate reductase, the Equi biovar can survive in absence of oxygen. On the other hand, Ovis biovar that does not have nitrate reductase is able to adapt to various ecological niches and can grow on certain carbon sources. Apart from these two biovars, some other strains are also able to carry out the reduction of nitrate. The enzymes that are involved in electron transport chain are also identified by in silico methods. Findings about pathogen metabolism can contribute to the identification of relationship between nitrate reductase and the pathogenicity, virulence factors, and discovery of drug targets.
根据硝酸还原酶合成能力，其被分为两个生物变种：羊种和马种。由于存在硝酸还原酶，马种生物变种能够在无氧环境中存活。另一方面，不具有硝酸还原酶的羊种生物变种能够适应各种生态位，并能在某些碳源上生长。除了这两个生物变种外，其他一些菌株也能够进行硝酸盐还原。参与电子传递链的酶也通过计算机方法得以鉴定。关于病原体代谢的研究结果有助于确定硝酸还原酶与致病性、毒力因子之间的关系以及药物靶点的发现。
