Jenkins D J, Taylor R H, Nineham R, Goff D V, Bloom S R, Sarson D L, Misiewicz J J, Alberti K G
Department of Nutritional Sciences, Faculty of Medicine, St. Michael's Hospital, University of Toronto, Canada.
Am J Gastroenterol. 1988 Apr;83(4):393-7.
Preliminary data indicated that viscous fiber (guar) and alpha-glycosidase inhibition (acarbose) used in combination to slow carbohydrate absorption have an apparently additive effect in reducing the postprandial glycemic response. The full endocrine data reported here also demonstrate that reductions in insulin and gastric inhibitory polypeptide are most significant when guar and acarbose are used in combination. The results are divergent for enteroglucagon when guar and acarbose were given singly. Raised enterglucagon levels seen after acarbose are in keeping with inhibition of proximal absorption resulting in more distal absorption of carbohydrate. However, with viscous fiber, the enteroglucagon response was reduced, and this reduction was maintained even after addition of acarbose. The results demonstrate that the gut endocrine response can be manipulated by pharmacological interventions which alter the pattern of carbohydrate absorption.
初步数据表明，粘性纤维（瓜尔豆胶）和α-糖苷酶抑制剂（阿卡波糖）联合使用以减缓碳水化合物吸收，在降低餐后血糖反应方面具有明显的相加作用。此处报告的完整内分泌数据还表明，瓜尔豆胶和阿卡波糖联合使用时，胰岛素和胃抑制多肽的降低最为显著。单独使用瓜尔豆胶和阿卡波糖时，肠高血糖素的结果有所不同。阿卡波糖后肠高血糖素水平升高与近端吸收受到抑制导致碳水化合物更多地在远端吸收一致。然而，对于粘性纤维，肠高血糖素反应降低，即使添加阿卡波糖后这种降低仍持续存在。结果表明，肠道内分泌反应可通过改变碳水化合物吸收模式的药理学干预来调控。
