O'Dea K, Turton J
Am J Clin Nutr. 1985 Mar;41(3):511-6. doi: 10.1093/ajcn/41.3.511.
A major barrier to the widespread clinical use of an alpha-glucosidase inhibitor such as Acarbose, is the unpleasant gastrointestinal symptoms of carbohydrate malabsorption associated with its use. Acarbose is usually administered as a tablet and eaten with the first mouthful of the meal, making its uniform distribution through the meal unlikely. In the present study, Acarbose was crushed to a powder and mixed through a test meal before it was consumed. Six healthy young men consumed test meals containing 75 g carbohydrate either as whole brown rice or as ground brown rice. When Acarbose was uniformly mixed through a ground rice meal prior to digestion it produced dose-dependent reductions in the postprandial glucose, insulin and GIP responses which were evident at doses as low as 12.5 mg. The responses to whole brown rice were intermediate between those to 12.5 and 25 mg Acarbose in ground brown rice. In tablet form Acarbose was only one quarter as effective in flattening the post prandial glucose and insulin responses as it was in powder form. These results highlight the importance of uniform distribution of Acarbose through a carbohydrate meal in order to achieve maximum effectiveness in delaying digestion and absorption and yet not promoting carbohydrate malabsorption.
阿卡波糖这类α-葡萄糖苷酶抑制剂在临床上广泛应用的一个主要障碍，是其使用过程中伴随的碳水化合物吸收不良所带来的令人不适的胃肠道症状。阿卡波糖通常制成片剂，与第一口饭一起服用，这使得它不太可能在一顿饭中均匀分布。在本研究中，阿卡波糖被碾碎成粉末，并在食用前与测试餐混合。六名健康的年轻男性食用了含有75克碳水化合物的测试餐，碳水化合物分别为完整糙米或磨碎的糙米。当阿卡波糖在消化前均匀混合到磨碎的米饭餐中时，它会使餐后血糖、胰岛素和GIP反应产生剂量依赖性降低，低至12.5毫克的剂量时这种降低就很明显。对完整糙米的反应介于对磨碎糙米中12.5毫克和25毫克阿卡波糖的反应之间。以片剂形式服用时，阿卡波糖在平缓餐后血糖和胰岛素反应方面的效果仅为粉末形式的四分之一。这些结果凸显了阿卡波糖在碳水化合物餐中均匀分布的重要性，以便在延迟消化和吸收且不促进碳水化合物吸收不良方面达到最大效果。
