Popescu N C, Cheng S Y, Pastan I
Laboratory of Biology, National Cancer Institute, Bethesda, MD 20892.
Am J Hum Genet. 1988 Apr;42(4):560-4.
A cDNA for the gene that encodes for a human cellular thyroid hormone-binding protein (p55) has recently been isolated and sequenced. The sequence of p55 indicates that it is identical to the protein disulfide isomerase and the beta-subunit of prolyl 4-hydroxylase. By in situ hybridization, the gene for p55 was localized on chromosome 17 at band q25. This localization shows that the p55 gene is not linked to either erbA1 or erbA2; two other thyroid hormone-binding protein genes are located at 17q 11-21 and 3p21-pter, respectively. The localization of p55 gene will permit the evaluation of the possible effects of chromosome changes on the structure and activity of the p55 gene in chromosome syndromes or neoplasms.
最近已分离并测序了编码人细胞甲状腺激素结合蛋白（p55）的基因的互补DNA（cDNA）。p55的序列表明它与蛋白质二硫键异构酶和脯氨酰4-羟化酶的β亚基相同。通过原位杂交，p55基因定位于17号染色体q25带。这种定位表明p55基因与erbA1或erbA2均无连锁关系；另外两个甲状腺激素结合蛋白基因分别位于17q11 - 21和3p21 - pter。p55基因的定位将有助于评估染色体综合征或肿瘤中染色体变化对p55基因结构和活性的可能影响。
