人类17号染色体上的生长激素基因、绒毛膜促生长催乳素基因以及类生长激素基因。

Genes for growth hormone, chorionic somatommammotropin, and growth hormones-like gene on chromosome 17 in humans.

作者信息

Owerbach D, Rutter W J, Martial J A, Baxter J D, Shows T B

出版信息

Science. 1980 Jul 11;209(4453):289-92. doi: 10.1126/science.7384802.

Abstract

The human genes for growth hormone (GH), chorionic somatomammotropin (CSH), and a third growth hormone-like gene (GHL) have been located on chromosome 17 in humans. DNA fragments of 2.6, 2.8, and 9.5 kilobase pairs containing GH, CSH, and GHL, respectively, were identified in human genomic DNA, and a 7.5-kilobase DNA fragment related to growth hormone DNA sequences was found in mouse cells. In somatic hybrids of human and mouse cells containing reduced numbers of human chromosomes, but a normal complement of mouse chromosomes, the mouse, 7.5-kolobase DNA fragment was always present, whereas the 2.6-, 2.8-, and 9.5-kilobase human fragments were present only when human chromosome 17 was also present.

摘要

人类生长激素（GH）、绒毛膜促生长催乳素（CSH）以及第三种类生长激素基因（GHL）的基因已定位在人类的17号染色体上。在人类基因组DNA中分别鉴定出了包含GH、CSH和GHL的2.6、2.8和9.5千碱基对的DNA片段，并且在小鼠细胞中发现了一个与生长激素DNA序列相关的7.5千碱基DNA片段。在人类和小鼠细胞的体细胞杂种中，人类染色体数量减少，但小鼠染色体数量正常，小鼠的7.5千碱基DNA片段总是存在，而2.6、2.8和9.5千碱基的人类片段只有在人类17号染色体也存在时才会出现。