Yang Wanli, Ma Jiaojiao, Zhou Wei, Zhou Xin, Cao Bo, Fan Daiming, Hong Liu
a State key Laboratory of Cancer Biology, National Clinical Research Center for Digestive Diseases and Xijing Hospital of Digestive Diseases , Fourth Military Medical University , Xi'an , China.
Expert Rev Gastroenterol Hepatol. 2017 Jun;11(6):539-548. doi: 10.1080/17474124.2017.1309281. Epub 2017 Mar 27.
Hypoxia, a common feature of tumor microenvironment, is known to accelerate tumor development and growth by promoting the formation of a neoplastic environment. Recent studies have provided a wealth of evidence that miRNAs are significant members of the adaptive response to low oxygen in tumors. miR-210 is one of the hypoxia-induced miRNAs, which has been reported extensively in cancer researches. However, there is no systematic discussion about the role of miR-210 in gastrointestinal cancer. We conducted a literature research in database including PubMed, Elsevier Science Direct and Medline before 16 September 2016, in order to collect articles of miR-210 in gastrointestinal cancer. Areas covered: In the present review, we mainly discuss the following aspects: hypoxia-induced dysregulation of miR-210, the expression of miR-210 and tumorigenesis, the resultant changes of miR-210 targets and its roles in different types of gastrointestinal cancer progression, the diagnostic, therapeutic and prognostic value of miR-210 in gastrointestinal cancer. Expert commentary: Numerous researches have demonstrated the values of miR-210 in cancer diagnosis, prognosis and targeted therapies, especially in gastrointestinal cancers. However, there are also some existing problems and challenges in translating the new research findings into clinical utility. Further investigations and studies are still urgently required.
缺氧是肿瘤微环境的一个常见特征，已知它通过促进肿瘤环境的形成来加速肿瘤的发展和生长。最近的研究提供了大量证据表明，微小RNA（miRNAs）是肿瘤对低氧适应性反应的重要成员。miR-210是缺氧诱导的miRNAs之一，在癌症研究中已有广泛报道。然而，关于miR-210在胃肠道癌中的作用尚无系统的讨论。我们在2016年9月16日前对包括PubMed、爱思唯尔科学Direct和Medline在内的数据库进行了文献研究，以收集有关miR-210在胃肠道癌中的文章。涵盖领域：在本综述中，我们主要讨论以下方面：缺氧诱导的miR-210失调、miR-210的表达与肿瘤发生、miR-210靶标的变化及其在不同类型胃肠道癌进展中的作用、miR-210在胃肠道癌中的诊断、治疗和预后价值。专家评论：众多研究已证明miR-210在癌症诊断、预后和靶向治疗中的价值，尤其是在胃肠道癌中。然而，将新的研究结果转化为临床应用也存在一些现存问题和挑战。仍迫切需要进一步的调查和研究。
