Huang Ying, Ohno Osamu, Suenaga Kiyotake, Miyamoto Kenji
a Department of Biosciences & Informatics , Keio University , Yokohama , Japan.
b Department of Chemistry and Life Science , School of Advanced Engineering, Kogakuin University , Hachioji , Japan.
Biosci Biotechnol Biochem. 2017 Jun;81(6):1106-1113. doi: 10.1080/09168451.2017.1300517. Epub 2017 Mar 20.
Ninety samples from the extracts of plants from traditional Chinese medicines were screened for antitumor activity. Paeoniflorigenone (PFG) was isolated as an active ingredient from the root of moutan cortex, which showed the strongest activity. In addition, our data indicated that PFG was cytotoxic and induced apoptosis selectively in the cancer cell lines. These effects were cancelled by the addition of caspase inhibitor Z-VAD-FMK, suggesting that it was mediated by caspase-3 activation.
对90份来自中药植物提取物的样本进行了抗肿瘤活性筛选。从牡丹皮根部分离出活性成分芍药苷元酮（PFG），其显示出最强的活性。此外，我们的数据表明，PFG具有细胞毒性，并能在癌细胞系中选择性地诱导细胞凋亡。添加半胱天冬酶抑制剂Z-VAD-FMK可消除这些作用，表明其是由半胱天冬酶-3激活介导的。
