植物来源的新型酚类二聚体及其细胞毒性和一氧化氮生成抑制作用。
New Phenolic Dimers from Plant and Their Cytotoxicity and NO Production Inhibition.
机构信息
School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430074, China.
School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China.
出版信息
Molecules. 2023 Jun 6;28(12):4590. doi: 10.3390/molecules28124590.
The , known as 'Feng Dan', has been used for thousands of years in traditional Chinese medicine. In our chemical investigation on the root bark of the plant, five new phenolic dimers, namely, paeobenzofuranones A-E (-), were characterized. Their structures were determined using spectroscopic analysis including 1D and 2D NMR, HRESIMS, UV, and IR, as well as ECD calculations. Compounds , , and showed cytotoxicity against three human cancer cell lines, with IC values ranging from 6.7 to 25.1 μM. Compounds and showed certain inhibitory activity on NO production. To the best of our knowledge, the benzofuranone dimers and their cytotoxicity of are reported for the first time in this paper.
该植物的根皮在中药中使用了数千年，被称为“防风”。在对该植物根皮的化学成分研究中，我们鉴定了 5 个新的酚类二聚体，即 paeobenzofuranones A-E（-）。通过包括 1D 和 2D NMR、HRESIMS、UV 和 IR 以及 ECD 计算在内的光谱分析确定了它们的结构。化合物 、 、 和 对三种人癌细胞系表现出细胞毒性，IC 值范围为 6.7 至 25.1 μM。化合物 和 对 NO 生成具有一定的抑制活性。据我们所知，本文首次报道了苯并呋喃酮二聚体及其 对细胞的毒性。
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