Passeron Thierry
Department of Dermatology and INSERM U1065, Team 12, C3M, Archet 2 Hospital, University Hospital of Nice, 150 Route de Ginestière, Nice 06200, France.
Dermatol Clin. 2017 Apr;35(2):163-170. doi: 10.1016/j.det.2016.11.007.
Medical treatments alone, or in combination with phototherapy, are key approaches for treating nonsegmental vitiligo and, to a lesser extent, segmental vitiligo. The treatments are useful for halting disease progression and have been proven effective for inducing repigmentation and decreasing risk of relapses. Although the treatments have side effects and limitations, vitiligo often induces a marked decrease in quality of life and in most cases the risk:benefit ratio is in favor of an active approach. Systemic and topical agents targeting the pathways involved in loss of melanocytes and in differentiation of melanocyte stem cells should provide more effective approaches in the near future.
单独使用医学治疗方法，或与光疗联合使用，是治疗非节段性白癜风的关键方法，在较小程度上也是治疗节段性白癜风的关键方法。这些治疗方法有助于阻止疾病进展，并且已被证明在诱导色素再生和降低复发风险方面有效。尽管这些治疗方法有副作用和局限性，但白癜风常常会导致生活质量显著下降，而且在大多数情况下，风险与收益之比有利于采取积极的治疗方法。针对黑素细胞丢失和黑素细胞干细胞分化所涉及途径的全身性和局部用药在不久的将来应能提供更有效的治疗方法。
