Chang Yuqian, Zhang Shaolong, Zhang Weigang, Li Shuli, Li Chunying
Department of Dermatology, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Front Med (Lausanne). 2022 May 27;9:818543. doi: 10.3389/fmed.2022.818543. eCollection 2022.
The efficacy of camouflage combined with psychotherapy and the underlying mechanisms are poorly understood in vitiligo management. This study aimed to investigate the joint efficacy and further explore psycho-neuro-endocrine-immune-skin interactions.
In a prospective, non-randomized and concurrent controlled trial, patients were divided into two groups. Quality of life (QOL) was evaluated using the Chinese version of the Vitiligo Life Quality Index (VLQI-C). Serum levels of neuropeptides and cytokines were detected by enzyme-linked immunosorbent assay.
A total of 149 patients were included for final evaluation. After treatment for 4 weeks, total and subcategory quality of life scores in the intervention group were much lower than in the control group. Serum levels of neuropeptide-Y (NPY) and melanin-concentrating hormone (MCH) significantly decreased, and serum level of adrenocorticotropic hormone (ACTH) increased in both active and stable patients of the intervention group, but not in the control group. In addition, the serum levels of interferon-γ (IFN-γ), CXC chemokine ligand 10 (CXCL10), and interleukin-1β (IL-1β) decreased in both the active and stable patients of the intervention group and only in the active patients of the control group.
The combination of camouflage and psychotherapy provided a clinically meaningful improvement in quality of life and ameliorated the outcome by likely modulating the psycho-neuro-endocrine-immuno-skin system during vitiligo management.
www.clinicaltrials.gov/ct2/show/NCT03540966, identifier: NCT03540966.
在白癜风治疗中，伪装联合心理治疗的疗效及其潜在机制尚不清楚。本研究旨在探讨联合疗效，并进一步探索心理-神经-内分泌-免疫-皮肤之间的相互作用。
在一项前瞻性、非随机同期对照试验中，将患者分为两组。使用中文版白癜风生活质量指数（VLQI-C）评估生活质量。采用酶联免疫吸附测定法检测血清神经肽和细胞因子水平。
共有149例患者纳入最终评估。治疗4周后，干预组的总体生活质量得分和各子类别得分均显著低于对照组。干预组活动期和稳定期患者的血清神经肽Y（NPY）和黑色素浓缩激素（MCH）水平显著降低，促肾上腺皮质激素（ACTH）水平升高，而对照组无此变化。此外，干预组活动期和稳定期患者的血清干扰素-γ（IFN-γ）、CXC趋化因子配体10（CXCL10）和白细胞介素-1β（IL-1β）水平均降低，而对照组仅活动期患者的上述指标降低。
在白癜风治疗过程中，伪装与心理治疗相结合可在临床上显著改善生活质量，并可能通过调节心理-神经-内分泌-免疫-皮肤系统改善治疗效果。
www.clinicaltrials.gov/ct2/show/NCT03540966，标识符：NCT03540966。
