白癜风中通过黑素细胞再生实现色素再生

Repigmentation through Melanocyte Regeneration in Vitiligo.

作者信息

Birlea Stanca A, Goldstein Nathaniel B, Norris David A

机构信息

Department of Dermatology, University of Colorado Anschutz Medical Campus, 12801 17th Avenue, Aurora, CO 80045, USA.

出版信息

Dermatol Clin. 2017 Apr;35(2):205-218. doi: 10.1016/j.det.2016.11.015.

DOI:10.1016/j.det.2016.11.015

PMID:28317529

Abstract

Repigmentation in vitiligo is the process that replaces, in the epidermal basal layer of vitiligo skin, the mature melanocytes that have been killed by cytotoxic T cells specific for melanocyte antigens. It consists of mobilization of melanocyte precursors in the hair follicle bulge and infundibulum to proliferate, migrate, and differentiate into mature melanocytes, moving from the hair follicle bulge to the interfollicular epidermis. The most common clinical presentation of repigmentation in vitiligo is the perifollicular pattern. The most potent stimulus for repigmentation is the UV light.

摘要

白癜风的色素再生是指在白癜风皮肤的表皮基底层中，被针对黑素细胞抗原的细胞毒性T细胞杀死的成熟黑素细胞被替代的过程。它包括毛囊隆突部和漏斗部的黑素细胞前体动员起来增殖、迁移并分化为成熟黑素细胞，从毛囊隆突部迁移至毛囊间表皮。白癜风色素再生最常见的临床表现是毛囊周围模式。色素再生最有效的刺激因素是紫外线。