Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Rama IV Road, Pathumwan, Bangkok 10330, Thailand.
Sci Rep. 2017 Mar 20;7:44830. doi: 10.1038/srep44830.
The aim of this study was to compare the therapeutic efficacy of alginate-based reflux suppressant and magnesium-aluminium antacid gel for treatment of heartburn in pregnancy. A double-blinded, randomized, controlled trial was conducted. One hundred pregnant women at less than 36 weeks gestation with heartburn at least twice per week were randomized to either alginate-based reflux suppressant or to magnesium-aluminium antacid gel. Details of heartburn were recorded before beginning the treatment and the second week of study. Primary outcome measure was the improvement of heartburn frequency after treatment and secondary outcome were the improvement of heartburn intensity, quality of life, maternal satisfaction, maternal side effects, pregnancy and neonatal outcomes. There was no difference between treatment and control groups in improvement of heartburn frequency (80% vs 88%, p = 0.275), 50% reduction of frequency of heartburn (56% vs 52%, p = 0.688), improvement of heartburn intensity (92% vs 92%, p = 1.000) and 50% reduction of heartburn intensity (68% vs 80% cases, p = 0.075). There were also no significant differences in quality of life, maternal satisfaction, maternal side effects, pregnancy and neonatal outcomes. Alginate-based reflux suppressant was not different from magnesium-aluminium antacid gel in the treatment of heartburn in pregnancy.
本研究旨在比较藻酸盐类抑酸剂和镁铝抗酸凝胶治疗妊娠烧心的疗效。采用双盲、随机、对照试验。将 100 名妊娠不足 36 周、每周烧心至少 2 次的孕妇随机分为藻酸盐类抑酸剂组或镁铝抗酸凝胶组。在开始治疗前和研究的第二周记录烧心的详细情况。主要观察指标为治疗后烧心频率的改善，次要观察指标为烧心强度、生活质量、产妇满意度、产妇副作用、妊娠和新生儿结局的改善。治疗组和对照组在烧心频率改善方面无差异（80%比 88%，p=0.275），烧心频率减少 50%（56%比 52%，p=0.688），烧心强度改善（92%比 92%，p=1.000）和烧心强度减少 50%（68%比 80%，p=0.075）方面也无差异。生活质量、产妇满意度、产妇副作用、妊娠和新生儿结局也无显著差异。藻酸盐类抑酸剂在治疗妊娠烧心方面与镁铝抗酸凝胶无差异。
