Engström W, Barrios C, Azawedo E, Möllermark G, Kängström L E, Eliason I, Larsson O
Department of Tumour Pathology, Karolinska Hospital, Stockholm, Sweden.
Anticancer Res. 1987 Nov-Dec;7(6):1235-7.
The expression of the protooncogene c-myc was examined in twelve canine mammary tumours of different histological type. Only in one tumour--a poorly differentiated carcinoma--was the amount of RNA that hybridized with our cDNA probe for the myc gene significantly increased. Restriction fragment length analysis of genomic DNA from this tumour did not reveal any amplification or other rearrangements in this gene locus.
对12例不同组织学类型的犬乳腺肿瘤中原癌基因c-myc的表达进行了检测。仅在1例肿瘤（低分化癌）中，与我们用于myc基因的cDNA探针杂交的RNA量显著增加。对该肿瘤基因组DNA的限制性片段长度分析未发现该基因位点有任何扩增或其他重排。
