Engström W, Barrios C, Willems J S, Möllermark G, Kängström L E, Eliasson I, Larsson O
Department of Tumour Pathology, Karolinska Hospital, Stockholm, Sweden.
Anticancer Res. 1987 Nov-Dec;7(6):1109-10.
The expression of the protooncogene c-myc in a canine rhabdomyosarcoma was examined. It was found that this highly malignant tumour contained vast quantities of RNA that hybridized with a cDNA probe for c-myc. Restriction fragment length analysis after endonuclease digestion of tumour DNA did not reveal any rearrangements in this gene locus. The potential role of this oncogene in the development of canine rhabdomyosarcoma is discussed.
对犬横纹肌肉瘤中原癌基因c-myc的表达进行了检测。发现这种高度恶性肿瘤含有大量与c-myc的cDNA探针杂交的RNA。对肿瘤DNA进行核酸内切酶消化后的限制性片段长度分析未揭示该基因位点有任何重排。讨论了这种癌基因在犬横纹肌肉瘤发生发展中的潜在作用。
