Kozbor D, Croce C M
Cancer Res. 1984 Feb;44(2):438-41.
The c-myc oncogene was not rearranged in any of five different human breast carcinoma cell lines examined. A 10-fold amplification and an elevated expression of the oncogene were detected in one of these cell lines, and the four other lines expressed low or undetectable levels of c-myc transcripts. Thus, c-myc amplification and elevated expression may be found only in a minority of human breast carcinomas.
在所检测的五种不同人类乳腺癌细胞系中，c-myc癌基因均未发生重排。在其中一个细胞系中检测到该癌基因有10倍的扩增以及表达升高，而其他四个细胞系表达低水平或无法检测到的c-myc转录本。因此，c-myc扩增和表达升高可能仅在少数人类乳腺癌中出现。
