Department of Chemistry, Korea University, Seoul 02841, Korea.
Chem Soc Rev. 2017 Apr 18;46(8):2076-2090. doi: 10.1039/c6cs00719h.
Protons play crucial roles in many physiological and pathological processes, such as receptor-mediated signal transduction, ion transport, endocytosis, homeostasis, cell proliferation, and apoptosis. The urgent demand for pH imaging and measurement in biological systems has incited the development of fluorescent pH probes. Numerous fluorescent probes have been reported, but many lack the abilities needed for biological applications. Hence, the development of new pH probes with better biocompatibility, sensitivity, and site-specificity is still indispensable. This review highlights the recent trends in the development of fluorescent materials as essential tools for tracing pH variations in the biological processes of diverse living systems.
质子在许多生理和病理过程中发挥着关键作用，如受体介导的信号转导、离子转运、内吞作用、动态平衡、细胞增殖和细胞凋亡。对生物系统中 pH 成像和测量的迫切需求激发了荧光 pH 探针的发展。已经报道了许多荧光探针，但许多探针缺乏生物应用所需的能力。因此，开发具有更好的生物相容性、灵敏度和特异性的新型 pH 探针仍然是必不可少的。本综述重点介绍了荧光材料作为追踪不同生命系统生物过程中 pH 变化的重要工具的最新发展趋势。
