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用于智能医学的具有可控光物理性质的智能分子探针。

Smart molecular probes with controllable photophysical property for smart medicine.

作者信息

Kang Xiaoying, Du Zekun, Yang Shuxuan, Liang Mengyun, Liu Qian, Qi Ji

机构信息

State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials Ministry of Education, Frontiers Science Center for Cell Responses, and College of Life Sciences Nankai University Tianjin China.

Department of Urology Tianjin First Central Hospital Tianjin China.

出版信息

Smart Mol. 2024 Sep 4;2(3):e20240033. doi: 10.1002/smo.20240033. eCollection 2024 Sep.

DOI:10.1002/smo.20240033
PMID:40625916
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12118303/
Abstract

Precision medicine calls for advanced theranostics that integrate controllable diagnostic and therapeutic capabilities into one platform for disease treatment in the early stage. Phototheranostics such as fluorescence imaging (FLI), photoacoustic imaging (PAI), photodynamic therapy (PDT), and photothermal therapy (PTT) have attracted considerable attention in recent years, which mainly employ different excited-state energy dissipation pathways of a chromophore. According to the Jablonski diagram, FLI is related to the radiative process, PAI and PTT are derived from the nonradiative thermal deactivation, and PDT originates from the triplet state energy, in which these processes are usually competitive. Therefore, it is critically important to precisely tune the photophysical energy transformation processes to realize certain diagnosis and treatment properties in optimal state for boosting biomedical applications. Currently, there are mainly two strategies including chemical structure and aggregate behavior changes that relate to the regulation of excited state energy dissipation. In this review, we will discuss the recent advances of smart molecular probes that the photophysical properties can be regulated by external triggers and their applications in biomedical fields. We will summarize the development of activatable phototheranostic molecular probes in response to stimuli such as reactive oxygen species, pH, light, hypoxia, enzyme and gas. The assembly and disassembly of molecular aggregates that greatly affect the photophysical energy transformation processes will also be highlighted. This review aims to provide valuable insights into the development of more accurate diagnostic and therapeutic systems, thereby advancing the emerging field of smart medicine.

摘要

精准医学需要先进的诊疗技术，将可控的诊断和治疗能力集成到一个平台上，用于疾病的早期治疗。近年来，诸如荧光成像（FLI）、光声成像（PAI）、光动力疗法（PDT）和光热疗法（PTT）等光诊疗技术引起了广泛关注，它们主要利用发色团不同的激发态能量耗散途径。根据雅布隆斯基图，FLI与辐射过程有关，PAI和PTT源自非辐射热失活，而PDT起源于三重态能量，这些过程通常相互竞争。因此，精确调节光物理能量转换过程，以实现处于最佳状态的特定诊断和治疗特性，对于推动生物医学应用至关重要。目前，主要有两种策略，包括与激发态能量耗散调节相关的化学结构和聚集行为变化。在这篇综述中，我们将讨论光物理性质可由外部触发因素调节的智能分子探针的最新进展及其在生物医学领域的应用。我们将总结可激活的光诊疗分子探针在响应活性氧、pH值、光、缺氧、酶和气体等刺激时的发展情况。还将重点介绍对光物理能量转换过程有重大影响的分子聚集体的组装和解组装。这篇综述旨在为开发更精确的诊断和治疗系统提供有价值的见解，从而推动智能医学这一新兴领域的发展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/880b/12118303/afedb9b34021/SMO2-2-e20240033-g016.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/880b/12118303/3f7f437fd917/SMO2-2-e20240033-g019.jpg
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