Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan Province, China.
Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201601009. Epub 2017 Apr 27.
The aim of current meta-analysis was to investigate the relation between lycopene and risk of cardiovascular diseases (CVD).
Studies concerning about the association between lycopene and risk of CVD were searched on Pubmed, Embase, and Web of Science from inception to October 2016. A total of 14 eligible studies were identified. A significantly inverse association with a pooled risk ratio (RR) of 0.83 (95% CI: 0.76-0.90) was shown between lycopene exposure and risk of CVD. Findings were similar restricting to dietary studies (RR = 0.87, 95% CI = 0.79-0.96) and biomarker studies (RR = 0.74, 95% CI = 0. 62-0.87).Dietary lycopene intake was statistically significant for coronary heart disease (CHD) (RR: 0.87; 95% CI: 0.76-0.98) and stroke (RR: 0.83; 95% CI: 0.69-0.96).The pooled risk estimate was generally similar for lycopene biomarker concentrations, but the association was only statistically significant for stroke (RR: 0.65; 95% CI: 0.42-0.87). Subgroup analyses showed that retrospective and low quality studies were statistically significant sources of heterogeneity.
Higher lycopene exposure is inversely associated with a lower risk of CVD. Further well-designed randomized clinical trials are required to assess the role of lycopene on CVD.
本次荟萃分析旨在探讨番茄红素与心血管疾病（CVD）风险之间的关系。
本研究于 2016 年 10 月之前，通过检索 Pubmed、Embase 和 Web of Science 数据库，收集了关于番茄红素与 CVD 风险之间关系的相关研究。共纳入了 14 项符合标准的研究。结果显示，番茄红素暴露与 CVD 风险呈显著负相关，合并风险比（RR）为 0.83（95%可信区间：0.76-0.90）。仅纳入膳食研究（RR = 0.87，95%可信区间：0.79-0.96）和生物标志物研究（RR = 0.74，95%可信区间：0.62-0.87）时，结果相似。膳食番茄红素摄入量与冠心病（RR：0.87；95%可信区间：0.76-0.98）和中风（RR：0.83；95%可信区间：0.69-0.96）风险呈统计学显著相关。番茄红素生物标志物浓度的汇总风险估计值大致相似，但仅在中风（RR：0.65；95%可信区间：0.42-0.87）中具有统计学意义。亚组分析显示，回顾性研究和低质量研究是异质性的统计学显著来源。
较高的番茄红素暴露与较低的 CVD 风险呈负相关。需要进一步设计良好的随机临床试验来评估番茄红素对 CVD 的作用。
