在由G组链球菌引起的实验性主动脉瓣心内膜炎中，将LY146032与青霉素G进行比较。
LY146032 compared with penicillin G in experimental aortic valve endocarditis caused by group G streptococci.
作者信息
Bayer A S, Yih J, Hirano L
机构信息
Department of Medicine, Harbor-UCLA Medical Center, Torrance, California 90509.
出版信息
Antimicrob Agents Chemother. 1988 Jan;32(1):141-3. doi: 10.1128/AAC.32.1.141.
Abstract
Rabbits with group G streptococcal aortic endocarditis received no therapy (controls); repeated doses of procaine penicillin G, 300 mg/kg (body weight) per day, administered intramuscularly; or LY146032, a new peptolide antibiotic, 20 mg/kg per day, administered intravenously. Penicillin G and LY146032 reduced mean intravegetation group G streptococcal densities significantly below those observed in controls at both day 3 and day 6 of therapy. Penicillin G effected a more rapid clearance of intravegetation streptococci than LY146032 by day 3, but not by day 6, of therapy.
摘要
患有G组链球菌性主动脉心内膜炎的兔子未接受任何治疗（作为对照）；每天肌肉注射重复剂量的普鲁卡因青霉素G，剂量为300mg/kg（体重）；或每天静脉注射一种新的缩肽抗生素LY146032，剂量为20mg/kg。在治疗的第3天和第6天，青霉素G和LY146032均使赘生物内G组链球菌的平均密度显著低于对照组。在治疗的第3天，青霉素G比LY146032能更快速地清除赘生物内的链球菌，但在第6天并非如此。
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