实验性链球菌心内膜炎的化疗。II. 青霉素与链霉素对青霉素敏感链球菌的协同作用。
Chemotherapy of experimental streptococcal endocarditis. II. Synergism between penicillin and streptomycin against penicillin-sensitive streptococci.
作者信息
Durack D T, Pelletier L L, Petersdorf R G
出版信息
J Clin Invest. 1974 Mar;53(3):829-33. doi: 10.1172/JCI107622.
Abstract
Bacterial endocarditis was produced by intravenous injection of Streptococcus viridans into rabbits with preexisting sterile endocardial vegetations. After 6 h had elapsed, bacteria in the vegetations could not be eradicated by brief treatment with antimicrobials to which the streptococci were sensitive. However, when treatment with penicillin was continued for 4 days, the animals were cured. The 6-h infection therefore offered a model in which treatments could be conveniently compared over a short period. Synergism was demonstrated between penicillin and streptomycin in endocarditis due to a fully penicillin-sensitive streptococcus, a point which had not been previously proved in vivo. The clinical implications are discussed.
摘要
通过向预先存在无菌性心内膜赘生物的兔子静脉注射草绿色链球菌来诱发细菌性心内膜炎。6小时后，赘生物中的细菌不能通过用链球菌敏感的抗菌药物进行短暂治疗而被根除。然而，当用青霉素持续治疗4天时，动物被治愈。因此，6小时的感染提供了一个可以在短时间内方便地比较治疗方法的模型。在由对青霉素完全敏感的链球菌引起的心内膜炎中，青霉素和链霉素之间显示出协同作用，这一点以前在体内尚未得到证实。文中讨论了其临床意义。
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Experimental bacterial endocarditis. I. Colonization of a sterile vegetation.实验性细菌性心内膜炎。I. 无菌赘生物的定植
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Experimental bacterial endocarditis. 3. Production and progress of the disease in rabbits.实验性细菌性心内膜炎。3. 家兔疾病的产生与进展
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