Flap endonuclease-1 rs174538 G>A 多态性与中国人群食管癌风险相关。
Flap endonuclease-1 rs174538 G>A polymorphisms are associated with the risk of esophageal cancer in a Chinese population.
机构信息
Department of Cardiothoracic Surgery, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Department of Rheumatology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
出版信息
Thorac Cancer. 2017 May;8(3):192-196. doi: 10.1111/1759-7714.12422. Epub 2017 Mar 20.
BACKGROUND
Esophageal cancer has a high mortality rate, particularly in Asia, and there are obvious racial differences in regard to incidence. The purpose of our study was to assess the genetic susceptibility of functional single nucleotide polymorphisms in flap endonuclease-1 (FEN1) in esophageal squamous cell carcinoma ESCC.
METHODS
Clinical blood samples of 629 ESCC cases and 686 control samples were collected. The ligation detection reaction method was used to determine FEN 1 rs174538 G>A genotypes.
RESULTS
A significantly decreased risk of ESCC was associated with FEN1 rs174538 GA genotypes among patients under 63 years old.
CONCLUSIONS
Our results suggest that functional polymorphism FEN1 rs174538 G>A might affect personal susceptibility to ESCC. This result provides a solid theoretical foundation for further clinical study using larger sample sizes.
背景
食管癌死亡率高，尤其在亚洲，且发病率存在明显的种族差异。本研究旨在评估 FEN1（flap endonuclease-1）基因中功能性单核苷酸多态性与食管鳞癌（ESCC）易感性的关系。
方法
收集 629 例 ESCC 病例和 686 例对照的临床血样。采用连接酶检测反应法检测 FEN1 rs174538 G>A 基因型。
结果
63 岁以下患者中，FEN1 rs174538 GA 基因型与 ESCC 风险显著降低相关。
结论
本研究结果提示，FEN1 rs174538 G>A 功能性多态性可能影响 ESCC 的个体易感性。该结果为进一步使用更大样本量进行临床研究提供了坚实的理论基础。
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