Clinical Department of Neurology, Osijek University Hospital Center, J. Huttlera 4, HR-31000, Osijek, Croatia.
School of Medicine, Josip Juraj Strossmayer University in Osijek, Osijek, Croatia.
Neurol Sci. 2018 Oct;39(10):1691-1695. doi: 10.1007/s10072-018-3480-5. Epub 2018 Jun 30.
Parkinson's disease (PD) is a neurodegenerative disease with many motor and non-motor symptoms. Hyperhomocysteinemia is reported in many PD patients. Homocysteine (Hcy) is reported to be a risk factor for some PD non-motor symptoms.
The aim was to analyze Hcy level and its correlation with physical activity and motor and some non-motor symptoms (depression and cognition) in PD patients.
Patients were surveyed for physical activity and demographic data. Blood samples were obtained for Hcy, vitamin B12, and folic acid determination. The Mini Nutritional Assessment (MNA), Unified Parkinson's Disease Rating Scale (UPDRS) parts III and IV, Hoehn and Yahr (H&Y) Scale, Beck Depression Inventory (BDI), and Mini Mental State Examination (MMSE) were used to assess nutritional status, disease stage, and motor and some non-motor symptoms (depression and cognition) of PD in study patients.
We analyzed 34 PD patients. Elevated Hcy level was found in 70.6% of these patients. Patients reporting regular exercise had lower Hcy level (p < 0.025). Hcy level yielded a statistically significant correlation with MNA score (rs = - 0.510; p < 0.003), UPDRS part III (rs = 0.372; p < 0.030), vitamin B12 (rs = - 0.519; p < 0.002), and folic acid (rs = - 0.502; p < 0.003) but not with cognition and depression. There were no statistically significant differences in Hcy level for disease stage either for dyskinesia or "off" periods.
PD patients are at a risk of hyperhomocysteinemia. Regular physical activity decreases Hcy level, whereas poor motor function increases it. There is correlation between Hcy level and malnutrition in PD patients.
帕金森病（PD）是一种神经退行性疾病，具有许多运动和非运动症状。许多 PD 患者存在高同型半胱氨酸血症。同型半胱氨酸（Hcy）被报道为一些 PD 非运动症状的危险因素。
分析 PD 患者的 Hcy 水平及其与体力活动以及运动和一些非运动症状（抑郁和认知）的相关性。
调查患者的体力活动和人口统计学数据。采集血液样本以测定 Hcy、维生素 B12 和叶酸。使用 Mini Nutritional Assessment（MNA）、统一帕金森病评定量表（UPDRS）第 III 和 IV 部分、Hoehn 和 Yahr（H&Y）量表、贝克抑郁量表（BDI）和简易精神状态检查（MMSE）评估研究患者的营养状况、疾病阶段以及运动和一些非运动症状（抑郁和认知）。
我们分析了 34 名 PD 患者。这些患者中有 70.6%存在 Hcy 水平升高。报告定期运动的患者 Hcy 水平较低（p<0.025）。Hcy 水平与 MNA 评分呈统计学显著相关（rs=-0.510；p<0.003）、UPDRS 第 III 部分（rs=0.372；p<0.030）、维生素 B12（rs=-0.519；p<0.002）和叶酸（rs=-0.502；p<0.003），但与认知和抑郁无关。在疾病阶段、运动障碍或“关期”，Hcy 水平也没有统计学显著差异。
PD 患者存在高同型半胱氨酸血症的风险。定期体力活动可降低 Hcy 水平，而运动功能差则会升高 Hcy 水平。PD 患者的 Hcy 水平与营养不良之间存在相关性。
