Borodinova A A, Zuzina A B, Balaban P M
Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485, Russia.
Biochemistry (Mosc). 2017 Mar;82(3):243-256. doi: 10.1134/S0006297917030026.
Investigation of biochemical mechanisms underlying the long-term storage of information in nervous system is one of main problems of modern neurobiology. As a molecular basis of long-term memory, long-term changes in kinase activities, increase in the level and changes in the subunit composition of receptors in synaptic membranes, local activity of prion-like proteins, and epigenetic modifications of chromatin have been proposed. Perhaps a combination of all or of some of these factors underlies the storage of long-term memory in the brain. Many recent studies have shown an exclusively important role of atypical protein kinases (PKCζ, PKMζ, and PKCι/λ) in processes of learning, consolidation and maintenance of memory. The present review is devoted to consideration of mechanisms of transcriptional and translational control of atypical protein kinases and their roles in induction and maintenance of long-term synaptic plasticity and memory in vertebrates and invertebrates.
对神经系统中信息长期存储背后的生化机制进行研究是现代神经生物学的主要问题之一。作为长期记忆的分子基础，有人提出激酶活性的长期变化、突触膜中受体水平的增加和亚基组成的变化、朊病毒样蛋白的局部活性以及染色质的表观遗传修饰。也许所有这些因素或其中一些因素的组合是大脑中长期记忆存储的基础。最近的许多研究表明，非典型蛋白激酶（PKCζ、PKMζ和PKCι/λ）在学习、记忆巩固和维持过程中具有极其重要的作用。本综述致力于探讨非典型蛋白激酶的转录和翻译控制机制及其在脊椎动物和无脊椎动物长期突触可塑性和记忆的诱导和维持中的作用。
