Vetrovoy O V, Rybnikova E A, Samoilov M O
Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg, 199034, Russia.
Biochemistry (Mosc). 2017 Mar;82(3):392-400. doi: 10.1134/S000629791703018X.
This review analyzes recent data on mechanisms of cerebral hypoxia and the protective methods of hypoxic and ischemic postconditioning, as well as their interrelationship with the key mechanisms responsible for neuroprotection and neuroplasticity. Upregulation of expression of antiapoptotic factors and neurotrophins and modulation of activity of several protein kinases and transcription factors such as hypoxia-inducible factor-1 (HIF-1) are considered as the most important aspects in the neuroprotective potential of postconditioning. The presented information indicates substantial transformative promise of the noninvasive techniques of hypoxic postconditioning as well as significant similarity between the adaptive pathways activated by various postconditioning methods, which are far from being fully understood.
本综述分析了近期关于脑缺氧机制、缺氧缺血后处理保护方法及其与神经保护和神经可塑性关键机制之间相互关系的数据。抗凋亡因子和神经营养因子表达上调以及几种蛋白激酶和转录因子（如缺氧诱导因子-1，HIF-1）活性的调节被认为是后处理神经保护潜力的最重要方面。所呈现的信息表明，缺氧后处理的非侵入性技术具有巨大的变革前景，并且各种后处理方法激活的适应性途径之间存在显著相似性，而这些途径远未被完全理解。
