Sapse A M, Allen E B, Fugler-Domenico L
City University of New York, Graduate Center, New York 10019.
Cancer Invest. 1987;5(6):559-66. doi: 10.3109/07357908709020316.
Self-consistent (Hartree-Fock) calculations of the process of decomposition of protonated and lithiated syn-N-nitrosourea show that the presence of cations perturbs the electron distribution significantly. The decomposition of nitrosourea is facilitated when a proton or lithium ion is positioned at the oxygen of the nitroso group. These results may suggest clinical experimentation with nitrosoureas used in conjunction with lithium salts.
对质子化和锂化顺式-N-亚硝基脲分解过程进行自洽（哈特里-福克）计算表明，阳离子的存在会显著扰乱电子分布。当质子或锂离子位于亚硝基的氧原子处时，亚硝基脲的分解会更容易。这些结果可能意味着要对与锂盐联合使用的亚硝基脲进行临床试验。
