Schwingshackl Lukas, Chaimani Anna, Hoffmann Georg, Schwedhelm Carolina, Boeing Heiner
German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Arthur-Scheunert-Allee 114-116, 14558, Nuthetal, Germany.
Department of Hygiene and Epidemiology University of Ioannina School of Medicine, Medical School Campus, University of Ioannina, 45110, Ioannina, Greece.
Syst Rev. 2017 Mar 20;6(1):57. doi: 10.1186/s13643-017-0455-1.
Dietary advice is one of the cornerstones in the management of type 2 diabetes mellitus. The American Diabetes Association recommended a hypocaloric diet for overweight or obese adults with type 2 diabetes in order to induce weight loss. However, there is limited evidence on the optimal approaches to control hyperglycemia in type 2 diabetes patients. The aim of the present study is to assess the comparative efficacy of different dietary approaches on glycemic control and blood lipids in patients with type 2 diabetes mellitus in a systematic review including a standard pairwise and network meta-analysis of randomized trials.
We will conduct searches in Cochrane Central Register of Controlled Trials (CENTRAL) on the Cochrane Library, PubMed (from 1966), and Google Scholar. Citations, abstracts, and relevant papers will be screened for eligibility by two reviewers independently. Randomized controlled trials (with a control group or randomized trials with at least two intervention groups) will be included if they meet the following criteria: (1) include type 2 diabetes mellitus, (2) include patients aged ≥18 years, (3) include dietary intervention (different type of diets: e.g., Mediterranean dietary pattern, low-carbohydrate diet, low-fat diet, vegetarian diet, high protein diet); either hypo, iso-caloric, or ad libitum diets, (4) minimum intervention period of 12 weeks. For each outcome measure of interest, random effects pairwise and network meta-analyses will be performed in order to determine the pooled relative effect of each intervention relative to every other intervention in terms of the post-intervention values (or mean differences between the changes from baseline value scores). Subgroup analyses are planned for study length, sample size, age, and sex.
This systematic review will synthesize the available evidence on the comparative efficacy of different dietary approaches in the management of glycosylated hemoglobin (primary outcome), fasting glucose, and cardiovascular risk factors in type 2 diabetes mellitus patients. The results of the present network meta-analysis will influence evidence-based treatment decisions since it will be fundamental for based recommendations in the management of type 2 diabetes.
PROSPERO 42016047464.
饮食建议是2型糖尿病管理的基石之一。美国糖尿病协会建议超重或肥胖的2型糖尿病成年患者采用低热量饮食以实现体重减轻。然而，关于2型糖尿病患者控制血糖的最佳方法的证据有限。本研究的目的是通过一项系统评价（包括对随机试验的标准成对和网状荟萃分析）来评估不同饮食方法对2型糖尿病患者血糖控制和血脂的比较疗效。
我们将在Cochrane图书馆的Cochrane对照试验中心注册库（CENTRAL）、PubMed（自1966年起）和谷歌学术上进行检索。两名评审员将独立筛选文献、摘要和相关论文以确定其是否符合纳入标准。符合以下标准的随机对照试验（有对照组或至少有两个干预组的随机试验）将被纳入：（1）纳入2型糖尿病患者；（2）纳入年龄≥18岁的患者；（3）纳入饮食干预（不同类型的饮食：如地中海饮食模式、低碳水化合物饮食、低脂饮食、素食饮食、高蛋白饮食）；低热量、等热量或自由进食饮食；（4）最短干预期为12周。对于每个感兴趣的结局指标，将进行随机效应成对和网状荟萃分析，以确定各干预措施相对于其他干预措施在干预后值（或基线值得分变化之间的平均差异）方面的合并相对效应。计划对研究时长、样本量、年龄和性别进行亚组分析。
本系统评价将综合关于不同饮食方法在2型糖尿病患者糖化血红蛋白（主要结局指标）、空腹血糖和心血管危险因素管理方面比较疗效的现有证据。本网状荟萃分析的结果将影响基于证据的治疗决策，因为它对于2型糖尿病管理中的循证推荐至关重要。
PROSPERO 42016047464
