动粒上的动力蛋白：建立联系。
Dynein at kinetochores: Making the connection.
作者信息
McHugh Toni, Welburn Julie P I
机构信息
Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK.
Wellcome Trust Centre for Cell Biology, School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3BF, Scotland, UK
出版信息
J Cell Biol. 2017 Apr 3;216(4):855-857. doi: 10.1083/jcb.201703054. Epub 2017 Mar 20.
Dynein removes the checkpoint proteins from kinetochores once chromosomes are bioriented. In this issue, Gama et al. (2017. https://doi.org/10.1083/jcb.201610108) and Mosalaganti et al. (2017. https://doi.org/10.1083/jcb.201611060) reveal the molecular basis for how dynein and its adaptor protein Spindly are recruited to the ROD-Zw10-Zwilch complex in the fibrous corona of unattached kinetochores.
一旦染色体双定向，动力蛋白就会从动粒上去除检查点蛋白。在本期中，加马等人（2017年。https://doi.org/10.1083/jcb.201610108）和莫萨拉甘蒂等人（2017年。https://doi.org/10.1083/jcb.201611060）揭示了动力蛋白及其衔接蛋白纺锤体如何被招募到未附着动粒纤维冠中的ROD-Zw10-Zwilch复合体的分子基础。
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