Ino Kazuko, Nakase Kazunori, Nakamura Akiko, Nakamori Yoshiki, Sugawara Yumiko, Miyazaki Kana, Monma Fumihiko, Fujieda Atsushi, Sugimoto Yuka, Ohishi Kohshi, Masuya Masahiro, Katayama Naoyuki
Department of Hematology and Oncology, Mie University Hospital, Japan.
Intern Med. 2017;56(6):707-711. doi: 10.2169/internalmedicine.56.7647. Epub 2017 Mar 17.
Pulmonary mucormycosis (PM) is a life-threatening fungal infection in patients with hematologic malignancies, and early and accurate diagnostic modalities are urgently needed. We conducted a polymerase chain reaction (PCR) assay targeting these fungi in peripheral blood from four patients with hematologic malignancies who were strongly suspected of having PM. In these four patients, the Rhizopus species was identified in two patients, and the Cunninghamella and Absidia species in one each. Based on these molecular findings, all of the patients were successfully treated via targeted therapy with liposomal amphotericin B. In this report, a PCR analysis proved very useful for managing PM in patients with hematologic malignancies.
肺毛霉病（PM）是血液系统恶性肿瘤患者中一种危及生命的真菌感染，迫切需要早期准确的诊断方法。我们对4例高度怀疑患有PM的血液系统恶性肿瘤患者的外周血进行了针对这些真菌的聚合酶链反应（PCR）检测。在这4例患者中，2例鉴定为根霉属，1例为小克银汉霉属，1例为犁头霉属。基于这些分子检测结果，所有患者均通过脂质体两性霉素B靶向治疗成功治愈。在本报告中，PCR分析被证明对血液系统恶性肿瘤患者的PM治疗非常有用。
