Aljerf Loai, Alhaffar Iyad
Department of Life Sciences, Faculty of Dentistry, University of Damascus, Damascus, Syria.
Department of Oral Medicine, Faculty of Dentistry, University of Damascus, Damascus, Syria.
Biochem Res Int. 2017;2017:9596202. doi: 10.1155/2017/9596202. Epub 2017 Feb 21.
Oral diseases associated with systematic diseases as metabolic and vasculitic have been included in this paper. This will enhance our understanding of the salivary function in promoting healthy oral condition. The study investigates the effects of type I and type II diabetes mellitus in well-controlled diabetic patients, in addition to on saliva flow rate (SFR), pH, the decay, missing, and filled tooth (DMFT) index, glucose, and major earth-alkaline ions (Ca and Mg) compared to healthy males and age-matched controls. Saliva samples were collected from 1403 male human subjects, distributed on 7 levels including 3 control groups, and analyzed. The symptoms and clinical observations were enrolled. A preprandial salivary glucose has illustrated statistically strong significant and positive correlations with HbA and blood glucose levels. TIDM saliva showed lower pH, SFR, and Ca but higher Mg, caries risk, and poor metabolic control. These led to dysfunction of secretory capacity of salivary glands. TIIDM proved higher SFR, DMFT, and glucose than TIDM patients. DM oral calcium has decreased by age while magnesium sharply slopes at seniority. BD oral fluid is associated with lower glucose and minerals but noticeably with both higher pH and DMFT.
本文纳入了与代谢和血管炎等系统性疾病相关的口腔疾病。这将增进我们对唾液功能在促进口腔健康状况方面的理解。该研究调查了病情得到良好控制的I型和II型糖尿病患者与健康男性及年龄匹配的对照组相比，对唾液流速（SFR）、pH值、龋失补牙（DMFT）指数、葡萄糖以及主要碱土金属离子（钙和镁）的影响。从1403名男性受试者中采集唾液样本，这些受试者分布在包括3个对照组在内的7个水平组中，并进行了分析。记录了症状和临床观察结果。空腹唾液葡萄糖与糖化血红蛋白（HbA）和血糖水平在统计学上呈现出极强的显著正相关。I型糖尿病患者的唾液pH值、SFR和钙含量较低，但镁含量、龋齿风险和代谢控制较差。这些导致唾液腺分泌能力出现功能障碍。II型糖尿病患者的SFR、DMFT和葡萄糖水平高于I型糖尿病患者。糖尿病患者口腔中的钙含量随年龄下降，而镁含量在老年时急剧下降。患有灼口综合征（BD）的患者口腔液体中的葡萄糖和矿物质含量较低，但pH值和DMFT均明显较高。
