Biomedical Research Unit, Mexican Social Security Institute, Predio Canoas 100, Col. Los Angeles, 34067 Durango, Dgo. Mexico.
Magnes Res. 2011 Dec;24(4):156-62. doi: 10.1684/mrh.2011.0299.
A growing body of evidence from experimental studies that shows the essential role that magnesium exerts on glucose metabolism has been developed in last years, strongly suggesting that magnesium could plays an important roles in the reduction of the risk of developing type 2 diabetes. In the clinical setting, large epidemiological studies show that low dietary magnesium intake is associated with the increased risk of developing type 2 diabetes; however, results from randomized controlled clinical trials that have evaluated the beneficial effects of magnesium supplementation on glucose metabolism and insulin sensitivity are controversial. In this article we searched (in the electronic databases of Medline, Embase, and the Cochrane Controlled Trials Register up to June 2011) the evidence derived from epidemiological studies and clinical trials, about the relationship between magnesium and type 2 diabetes. The body of evidence from epidemiological studies consistently shows a strong inverse relationship between dietary magnesium intake and the risk of developing T2D; however, results from clinical trials are scarce and controversial.
近年来，越来越多的实验研究证据表明镁对葡萄糖代谢起着重要作用，这强烈提示镁在降低 2 型糖尿病风险方面可能发挥重要作用。在临床环境中，大型流行病学研究表明，低镁饮食摄入与 2 型糖尿病风险增加有关；然而，评估镁补充对葡萄糖代谢和胰岛素敏感性的有益效果的随机对照临床试验的结果存在争议。在本文中，我们检索了（截至 2011 年 6 月，在 Medline、Embase 和 Cochrane 对照试验登记处的电子数据库中）来自流行病学研究和临床试验的证据，关于镁与 2 型糖尿病之间的关系。来自流行病学研究的证据表明，饮食镁摄入与 2 型糖尿病风险之间存在很强的反比关系；然而，临床试验的结果很少且存在争议。
