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垂体腺瘤与高催乳素血症伴特发性肉芽肿性乳腺炎

Pituitary Adenoma and Hyperprolactinemia Accompanied by Idiopathic Granulomatous Mastitis.

作者信息

Destek Sebahattin, Gul Vahit Onur, Ahioglu Serkan, Serin Kursat Rahmi

机构信息

Department of General Surgery, Bezmialem Vakıf University School of Medicine, Istanbul, Turkey.

General Surgery Department, Edremit Government Hospital, Edremit, 10300 Balikesir, Turkey.

出版信息

Case Rep Endocrinol. 2017;2017:3974291. doi: 10.1155/2017/3974291. Epub 2017 Feb 22.

Abstract

Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of the breast, and its etiology remains not fully elucidated. IGM is observed more often in patients with autoimmune disease. Hyperprolactinemia is observed during pregnancy, lactation, and a history of oral contraceptive use. A 39-year-old patient with no history of oral contraceptive use presented with complaints such as redness, pain, and swelling in her left breast. Ultrasound and magnetic resonance imaging (MRI) revealed a suspicious inflamed mass lesion. Core biopsy was performed to exclude breast cancer and to further diagnose. The breast abscess was drained and steroids were given for treatment. In order to monitor any progression during the three months of treatment, hormone levels were routinely examined. Prolactin level was above the reference range, and pituitary MRI revealed a pituitary prolactinoma. After treatment with prolactin inhibitors, IGM also improved with hyperprolactinemia. This report emphasizes attention to hyperprolactinemia in cases of IGM diagnosis and treatment.

摘要

特发性肉芽肿性乳腺炎(IGM)是一种罕见的乳腺慢性炎症性疾病,其病因尚未完全阐明。IGM在自身免疫性疾病患者中更为常见。高催乳素血症在妊娠、哺乳期以及有口服避孕药史的患者中较为常见。一名无口服避孕药史的39岁患者出现左乳发红、疼痛和肿胀等症状。超声和磁共振成像(MRI)显示有可疑的炎性肿块病变。进行了核心活检以排除乳腺癌并进一步诊断。对乳腺脓肿进行了引流,并给予类固醇进行治疗。为了在治疗的三个月期间监测病情进展,常规检查了激素水平。催乳素水平高于参考范围,垂体MRI显示垂体催乳素瘤。在用催乳素抑制剂治疗后,IGM随着高催乳素血症的改善而好转。本报告强调在IGM的诊断和治疗中要关注高催乳素血症。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da13/5340950/1e86b8adc50e/CRIE2017-3974291.001.jpg

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