Sumeet Gupta, Rachna Kumria, Samrat Chauhan, Ipshita Chattopadhyaya, Vikas Jhawat, Manu Sharma
Department of Pharmacology, M. M. College of Pharmacy, M. M. University, Mullana, (Ambala), Haryana, India.
Swift College of Pharmacy, Ghaggar Sarai, Rajpura Punjab, India.
Curr Drug Deliv. 2018 Feb 14;15(2):205-214. doi: 10.2174/1567201814666170320142851.
Inflammation is the key mediator for arthritis. Plant based products are most useful for treating various disorders, but at the same time drug absorption is utmost important for effective therapy. The present aim of our study was to find out the therapeutic concern in pharmacokinetic and pharmacodynamic parameters in an arthritis induced rat model.
Carregenan and complete Freud's adjuvant, both were used for an arthritis induction as an animal model. Formulation of curcumin was prepared in different quality of milk brand, high fat milk with ghee and in an aqueous suspension. They were administered orally to the rats for 21 days continuously. Different pharmacodyanmic parameters were analyzed which include percentage inhibition of inflammation, cytokines (IL-6 and TNF-α), hematological levels, X-Rays and histology condition. Pharmacokinetics was also determined like Cmax, Tmax and Kel using HPLC method.
The result concludes that, curcumin in full fat milk with ghee and full fat curcumin formulation treated group showed a higher statistical significant effect in the prevention of inflammation in both the models. The presence of curcumin in plasma was higher only in full fat with ghee formulation and full fat milk formulation treated group when compared to the other groups.
Hence, it concludes that the presence of adjuvant act as an enhancer can increase the bioavailability of curcumin for achieving maximum effectiveness.
炎症是关节炎的关键介质。植物性产品对治疗各种疾病非常有用，但同时药物吸收对有效治疗至关重要。我们研究的当前目的是在关节炎诱导的大鼠模型中找出药代动力学和药效学参数方面的治疗关注点。
角叉菜胶和完全弗氏佐剂均用于诱导关节炎作为动物模型。姜黄素制剂在不同品质的牛奶品牌、含酥油的高脂肪牛奶以及水悬浮液中制备。将它们连续21天口服给予大鼠。分析了不同的药效学参数，包括炎症抑制百分比、细胞因子（IL-6和TNF-α）、血液学水平、X射线和组织学状况。还使用高效液相色谱法测定了药代动力学参数，如Cmax、Tmax和Kel。
结果表明，含酥油的全脂牛奶和全脂姜黄素制剂治疗组在两种模型中预防炎症方面均显示出更高的统计学显著效果。与其他组相比，仅含酥油的全脂制剂和全脂牛奶制剂治疗组血浆中姜黄素的含量更高。
因此，得出结论，佐剂作为增强剂的存在可以提高姜黄素的生物利用度，以实现最大疗效。
