融合肽HA2会损害靶向CXCR4的蛋白质纳米颗粒的选择性。
The fusogenic peptide HA2 impairs selectivity of CXCR4-targeted protein nanoparticles.
作者信息
Sánchez-García L, Serna N, Mattanovich M, Cazzanelli P, Sánchez-Chardi A, Conchillo-Solé O, Cortés F, Daura X, Unzueta U, Mangues R, Villaverde A, Vázquez E
机构信息
Institut de Biotecnologia i de Biomedicina and Departament de Genètica i de Microbiologia, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
Servei de Microscòpia, Universitat Autònoma de Barcelona, Bellaterra, 08193 Barcelona, Spain.
出版信息
Chem Commun (Camb). 2017 Apr 20;53(33):4565-4568. doi: 10.1039/c6cc09900a.
We demonstrate here that the genetic incorporation of the fusogenic peptide HA2 into a CXCR4-targeted protein nanoparticle dramatically reduces the specificity of the interaction between nanoparticles and cell receptors, a factor to be considered when designing tumor-homing drug vehicles displaying endosomal-escape agents. The loss of specificity is concomitant with enhanced cell penetrability.
我们在此证明，将融合肽HA2基因掺入靶向CXCR4的蛋白质纳米颗粒中，会显著降低纳米颗粒与细胞受体之间相互作用的特异性，这是设计展示内体逃逸剂的肿瘤归巢药物载体时需要考虑的一个因素。特异性的丧失与细胞穿透性增强同时发生。
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