放射性标记单克隆抗体S74在裸鼠人硬癌型胃癌异种移植物中的定位
Localization of radiolabeled monoclonal antibody S74 in human scirrhous type gastric cancer xenografts in nude mice.
作者信息
Yokota T, Takahashi T, Yamaguchi T, Otsuji E, Sawai K, Kitai S, Kitamura K, Noguchi A, Ahn T
机构信息
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
出版信息
Gastroenterol Jpn. 1987 Dec;22(6):698-702. doi: 10.1007/BF02776741.
A mouse monoclonal antibody (MoAb), S74 against a human scirrhous gastric carcinoma cell line was developed. The radioiodinated antibody bound preferentially in vivo to xenografted tumors rather than to normal tissue, whereas tumor uptake of normal mouse IgG did not occur. Thus this MoAb was able to selectively localize a human tumor in an animal model, and clinically it may enable immunotherapy against scirrhous carcinoma of the stomach.
制备了一种针对人硬癌性胃癌细胞系的小鼠单克隆抗体（MoAb）S74。放射性碘化抗体在体内优先结合异种移植肿瘤而非正常组织，而正常小鼠IgG则不发生肿瘤摄取。因此，这种单克隆抗体能够在动物模型中选择性地定位人肿瘤，在临床上它可能使针对胃硬癌的免疫治疗成为可能。
Zotero 插件