利用癌胚抗原抗体对人乳腺癌异种移植瘤进行定位
Localization of human breast-carcinoma xenografts using antibodies to carcinoembryonic antigen.
作者信息
Moshakis V, Bailey M J, Ormerod M G, Westwood J H, Neville A M
出版信息
Br J Cancer. 1981 May;43(5):575-81. doi: 10.1038/bjc.1981.86.
Abstract
Affinity-purified antibodies to carcinoembryonic antigen (CEA) have been injected into immune-suppressed mice bearing xenografts of human breast tumours. It has been shown that the antibodies localized in the tumours but not in normal tissues. The degree of tumour localization correlates with the amount of tumour CEA, and is unaffected by levels of circulating CEA or CEA/anti-CEA immune complexes.
摘要
已将癌胚抗原（CEA）的亲和纯化抗体注射到携带人乳腺肿瘤异种移植瘤的免疫抑制小鼠体内。结果表明，抗体定位于肿瘤中，而非正常组织。肿瘤定位程度与肿瘤CEA量相关，且不受循环CEA或CEA/抗CEA免疫复合物水平的影响。
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