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罗斯河病毒感染所致长期关节痛中促炎细胞因子水平升高。

Increased Proinflammatory Cytokine Levels in Prolonged Arthralgia in Ross River Virus Infection.

作者信息

Tappe Dennis, Pérez-Girón José Vicente, Gómez-Medina Sergio, Günther Stephan, Muñoz-Fontela César, Schmidt-Chanasit Jonas

出版信息

Emerg Infect Dis. 2017 Apr;23(4):702-704. doi: 10.3201/eid2304.160466.

DOI:10.3201/eid2304.160466
PMID:28322700
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5367403/
Abstract

Ross River virus, a mosquitoborne alphavirus, causes epidemic polyarthritis in Australia and the Pacific region. We analyzed serum cytokine, chemokine, and growth factor levels in travelers returning to Germany from Australia. Serum samples showed elevated concentrations in the acute phase of the illness and, more pronounced, in the long-lasting convalescent phase.

摘要

罗斯河病毒是一种由蚊子传播的甲病毒，在澳大利亚和太平洋地区引发流行性多关节炎。我们分析了从澳大利亚返回德国的旅行者血清中的细胞因子、趋化因子和生长因子水平。血清样本显示，在疾病急性期浓度升高，而在持久的恢复期更为明显。

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本文引用的文献

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Sustained Elevated Cytokine Levels during Recovery Phase of Mayaro Virus Infection.马亚罗病毒感染恢复期细胞因子水平持续升高。
Emerg Infect Dis. 2016 Apr;22(4):750-2. doi: 10.3201/eid2204.151502.
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Arthritogenic alphaviruses: new insights into arthritis and bone pathology.致关节炎的甲病毒：关节炎和骨病理学的新见解。
Trends Microbiol. 2015 Jan;23(1):35-43. doi: 10.1016/j.tim.2014.09.005. Epub 2014 Oct 30.
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Arthritogenic alphaviral infection perturbs osteoblast function and triggers pathologic bone loss.关节炎致病的甲型病毒感染会扰乱成骨细胞的功能，并引发病理性的骨质流失。
Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6040-5. doi: 10.1073/pnas.1318859111. Epub 2014 Apr 14.
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Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor.基孔肯雅热病毒感染引起的持续性关节痛与白细胞介素 6 和粒细胞巨噬细胞集落刺激因子有关。
J Infect Dis. 2011 Jan 15;203(2):149-57. doi: 10.1093/infdis/jiq042.
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Med Microbiol Immunol. 2009 Nov;198(4):271-3. doi: 10.1007/s00430-009-0122-9. Epub 2009 Sep 1.
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IL-1beta, IL-6, and RANTES as biomarkers of Chikungunya severity.白细胞介素-1β、白细胞介素-6和调节激活正常T细胞表达和分泌因子作为基孔肯雅热严重程度的生物标志物。
PLoS One. 2009;4(1):e4261. doi: 10.1371/journal.pone.0004261. Epub 2009 Jan 21.
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Macrophage-derived proinflammatory factors contribute to the development of arthritis and myositis after infection with an arthrogenic alphavirus.巨噬细胞衍生的促炎因子在感染致关节炎性甲病毒后会促进关节炎和肌炎的发展。
J Infect Dis. 2008 Jun 1;197(11):1585-93. doi: 10.1086/587841.
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Ross River virus transmission, infection, and disease: a cross-disciplinary review.罗斯河病毒的传播、感染与疾病：一项跨学科综述
Clin Microbiol Rev. 2001 Oct;14(4):909-32, table of contents. doi: 10.1128/CMR.14.4.909-932.2001.
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Arthritis Rheum. 2000 Feb;43(2):365-9. doi: 10.1002/1529-0131(200002)43:2<365::AID-ANR16>3.0.CO;2-E.