Trinh Binh T D, Quach Tam T T, Bui Dung N, Staerk Dan, Nguyen Lien-Hoa D, Jäger Anna K
Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, DK 2100 Copenhagen, Denmark; Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Natural Product and Medicinal Chemistry Lab, Faculty of Chemistry, Ho Chi Minh City University of Science, 227 Nguyen Van Cu, Ho Chi Minh City, Vietnam.
Fitoterapia. 2017 Apr;118:126-131. doi: 10.1016/j.fitote.2017.03.003. Epub 2017 Mar 16.
Three new xanthones, oblongixanthone F-H (1-3), along with eight known xanthones (4-11), were isolated from an EtOAc extract of the twigs of Garcinia oblongifolia. Their structures were elucidated by spectroscopic analysis including 1D- and 2D-NMR spectroscopy and mass spectrometry. The antidiabetic effects of all isolated compounds were evaluated by in vitro α-glucosidase and PTP1B inhibition assays. Compound 11 was the most active compound, and inhibited α-glucosidase and PTP1B with IC values of 1.7±0.5 and 14.1±3.5μM, respectively.
从长圆叶藤黄嫩枝的乙酸乙酯提取物中分离出三种新的呫吨酮，即长圆叶藤黄呫吨酮F - H（1 - 3），以及八种已知的呫吨酮（4 - 11）。通过包括一维和二维核磁共振光谱以及质谱在内的光谱分析阐明了它们的结构。通过体外α - 葡萄糖苷酶和蛋白酪氨酸磷酸酶1B（PTP1B）抑制试验评估了所有分离化合物的抗糖尿病作用。化合物11是活性最强的化合物，对α - 葡萄糖苷酶和PTP1B的抑制IC值分别为1.7±0.5和14.1±3.5μM。
