Faculty of Chemistry, VNUHCM-University of Science, Ho Chi Minh City, Vietnam.
Vietnam National University, Ho Chi Minh City, Vietnam.
Nat Prod Res. 2023 Jul-Aug;37(15):2541-2550. doi: 10.1080/14786419.2022.2055016. Epub 2022 Mar 25.
Two new xanthones, oblongixanthones I () and J (), and seven known compounds (-), were isolated from an EtOAc extract of the twigs of . Their structures were elucidated using spectroscopic methods, mainly 1 D and 2 D NMR. The antidiabetic effects of the two new compounds were evaluated using α-glucosidase and PTP1B inhibition assays. Both compounds displayed strong inhibition towards α-glucosidase with IC values of 258.7 ± 49.3 and 187.1 ± 27.5 μM, respectively (compared with acarbose, IC = 900.0 ± 3.0 μM) and moderate effects against PTP1B with IC values of 93.9 ± 12.3 and 64.1 ± 5.8 μM, respectively (compared with RK682, IC = 4.4 ± 0.3 l μM).
从八角枫科八角枫属植物的嫩枝的乙酸乙酯提取物中分离得到两个新的紫檀烷酮类化合物，长梗黄烷酮 I（）和 J（），以及 7 个已知化合物（-）。通过光谱方法，主要是 1D 和 2D NMR，阐明了它们的结构。使用 α-葡萄糖苷酶和 PTP1B 抑制测定法评估了这两种新化合物的抗糖尿病作用。这两种化合物对 α-葡萄糖苷酶均显示出强烈的抑制作用，IC 值分别为 258.7 ± 49.3 和 187.1 ± 27.5 μM（与阿卡波糖 IC = 900.0 ± 3.0 μM 相比），对 PTP1B 的抑制作用适中，IC 值分别为 93.9 ± 12.3 和 64.1 ± 5.8 μM（与 RK682 IC = 4.4 ± 0.3 μM 相比）。
