Shataer Dilireba, Chen Shaohua, Wu Yaodan, Liu Fen, Liu Haipeng, Lu Jing, Li Bailin, Zhao Liyun, Qiu Sheng-Xiang, Jumai Aikebaier
College of Smart Agriculture (Research Institute), Xinjiang University, Urumqi 830046, China.
Key Laboratory of National Forestry and Grassland Administration on Plant Conservation and Utilization in Southern China, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China.
Foods. 2025 Jul 1;14(13):2344. doi: 10.3390/foods14132344.
Metabolic syndrome has emerged as a significant global public health concern worldwide, characterized by a cluster of interrelated risk factors such as hypertension, hyperlipidemia, hyperglycemia, and abdominal obesity. In recent years, functional foods containing bioactive phytochemicals have attracted considerable scientific interest as potential therapeutic approaches for metabolic syndrome management. Xanthones, a class of naturally occurring tricyclic phenolic compounds abundant in various fruits and medicinal plants, demonstrate diverse biological activities relevant to metabolic health. This comprehensive review examines the dietary sources of xanthones, their bioactivity, and their promising role as functional food components for mitigating metabolic syndrome. The underlying mechanisms of action include modulation of lipid metabolism, improvement of insulin signaling pathways, potent anti-inflammatory and antioxidant effects, and modulation of glucose metabolism. Additionally, we discuss the stability and processing considerations of xanthones in food products. These findings highlight the development of xanthone-enriched functional foods and nutraceuticals as dietary interventions for metabolic syndrome prevention and management. This review comprehensively covers all relevant studies published up to the present without time restrictions.
代谢综合征已成为全球重大的公共卫生问题，其特征是高血压、高脂血症、高血糖和腹型肥胖等一系列相互关联的风险因素。近年来，含有生物活性植物化学物质的功能性食品作为代谢综合征管理的潜在治疗方法引起了相当大的科学关注。氧杂蒽酮是一类天然存在的三环酚类化合物，在各种水果和药用植物中含量丰富，具有与代谢健康相关的多种生物活性。这篇综述全面探讨了氧杂蒽酮的膳食来源、生物活性以及它们作为功能性食品成分在减轻代谢综合征方面的潜在作用。其潜在作用机制包括调节脂质代谢、改善胰岛素信号通路、强大的抗炎和抗氧化作用以及调节葡萄糖代谢。此外，我们还讨论了氧杂蒽酮在食品中的稳定性和加工注意事项。这些研究结果突出了富含氧杂蒽酮的功能性食品和营养保健品作为预防和管理代谢综合征的膳食干预措施的发展前景。这篇综述全面涵盖了截至目前所有相关研究，没有时间限制。
