在抗体不过量的条件下单纯疱疹病毒中和作用的不可重复性。
Irreproducibility of neutralization of herpes simplex virus under conditions where antibody is not in excess.
作者信息
Shariff D, Hallworth J A, Buchan A, Skinner G R
机构信息
Department of Medical Microbiology, University of Birmingham, UK.
出版信息
Intervirology. 1987;28(2):100-4. doi: 10.1159/000150001.
PMID:2832344
Abstract
Neutralizing activity against herpes simplex virus was significantly reduced if initial virus titers were greater than 10(6) PFU/ml; there was no significant neutralization when initial virus titers approached 10(8) PFU/ml. This was a result of utilization of all available antibody by virus particles and 'free' virus antigen and emphasizes the importance of conducting virus neutralization tests under conditions of antibody excess.
摘要
如果初始病毒滴度大于10⁶ PFU/ml，对单纯疱疹病毒的中和活性会显著降低；当初始病毒滴度接近10⁸ PFU/ml时，没有明显的中和作用。这是病毒颗粒和“游离”病毒抗原利用了所有可用抗体的结果，并强调了在抗体过量的条件下进行病毒中和试验的重要性。
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