女性生殖器疱疹患者中病毒抗原类型与抗体反应之间的关系。

Relationship between antigenic type of virus and antibody response in female patients with herpes genitalis.

作者信息

Ozaki Y, Ishiguro T, Ohashi M, Kimura E M

出版信息

J Med Virol. 1980;5(3):249-56. doi: 10.1002/jmv.1890050309.

Abstract

The antigenic types of virus recovered from genital sites in cases of adult female genital herpes and antibody response in these patients were investigated. Twelve strains were isolated from 23 clinical specimens, and half the number of the isolates was classified as type 1 virus and the remaining half as type 2 virus. The results of serological typing corresponded well to biological differentiation by plaque-forming ability on chick embryo cultures. The patients with type 1 virus infection had only the complement requiring neutralizing antibody, thus indicating a fresh infection. On the other hand, the noncomplement requiring neutralizing antibody was found in the patients with type 2 virus infection, indicating a later phase of infection.

摘要

对成年女性生殖器疱疹患者生殖器部位分离出的病毒抗原类型及这些患者的抗体反应进行了研究。从23份临床标本中分离出12株病毒，其中一半的分离株被归类为1型病毒，另一半为2型病毒。血清学分型结果与鸡胚培养物上通过蚀斑形成能力进行的生物学鉴别结果非常吻合。感染1型病毒的患者仅具有补体依赖中和抗体，因此表明是新感染。另一方面，在感染2型病毒的患者中发现了非补体依赖中和抗体，表明处于感染后期。